2024 Grant Report

2024 Grant Report

Year

Amount

Center

Researcher

Grant Name

Category

Type of Cancer

Subtype

2024

$125,000

Texas Children’s Cancer Center

Dr. Carl Allen

Defining Cell(s) of Origin and Clinical Risk in Langerhans Cell Histiocytosis


Langerhans Cell Histiocytosis



2024

$125,000

St. Jude Children’s Research Hospital

Dr. Sara Federico

HuNB803: A Safety Run-in and Phase 2 Randomized Trial of Chemoimmunotherapy Administered With and Without N-803, A Novel IL-15 Superagonist, for the Treatment of Patients With Relapsed or Refractory Neuroblastoma

Solid and Bone Cancers

Neuroblastoma


2024

$200,000

Memorial Sloan Kettering

Dr. Jason Lewis

Radiotherapeutic Targeting of Developmental Mutators in Childhood Solid Tumors as a Prelude to a New Clinical Trial for Children with Neuroblastomas and Other DLL3 Solid Tumors

Solid and Bone Cancers

Solid Tumors


2024

$200,000

Texas Children’s Cancer Center

Dr. Leonid Metelitsa

Developing Cytokine-armed CAR-NKT Immunotherapy for Neuroblastoma

Solid and Bone Cancers

Neuroblastoma


2024

$200,000

Seattle Children’s Hospital

Dr. Mignon Loh

Testing an Immunotherapy Drug/Molecule for Dual Recognition and Attachment to CD19 and CD33 Markers on MPAL Cancer Cells

Blood Cancer

Leukemia

Mixed-Phenotype Acute Leukemia (MPAL)

2024

$200,000

Dana-Farber Cancer Institute

Dr. Thomas Look

KAT6A/B Inhibitor Plus Isotretinoin and Anti-GD2 for High-Risk Neuroblastoma

Solid and Bone Cancers

Neuroblastoma


2024

$200,000

University of California San Francisco Benioff Children’s Hospital

Dr. Arun Wiita

Optimized Anti-CD70 CAR-NK Cells for the Treatment of Pediatric Acute Myeloid Leukemia

Blood Cancer

Leukemia

Acute Myeloid Leukemia (AML)

2023 & 2024

$100,000

Dana-Farber Cancer Institute

Dr. Scott Armstrong

Targeting Chromatin Complexes in NUP98-rearranged AML

Blood Cancer

Leukemia

Acute Myeloid Leukemia (AML)

2023 & 2024

$100,000

Memorial Sloan Kettering

Dr. Nai-Kong Cheung

Enhancing the Efficacy of GD2 Cancer Vaccine for High-risk Neuroblastoma by Augmenting Seroconversion

Solid and Bone Cancers

Neuroblastoma


2023 & 2024

$100,000

Texas Children’s Cancer Center

Dr. Meenakshi Hegde

Multi-center Clinical Testing of Autologous HER2 CAR T Cells and its Synergy with Surgical Resection in Recurrent Ependymoma

Brain Tumors

Ependymoma


2024

$350,000

Texas Children’s Cancer Center

Dr. Hedge

Provide Funding for Children on Trial Waiting List

Brain Tumors

Ependymoma


2023 & 2024

$100,000

Children’s Hospital of Philadelphia

Dr. John M. Maris

Functional Characterization and Armoring of Peptide-centric CAR T Cells to Enhance Efficacy

Solid and Bone Cancers

Neuroblastoma


2023 & 2024

$100,000

University of California San Francisco Benioff Children’s Hospital

Dr. Ross Okimoto

Exploiting DNA Repair Mechanisms to Overcome CIC-DUX4 Sarcoma

Solid and Bone Cancers

CIC-DUX4 Sarcoma 


2023 & 2024

$100,000

Seattle Children’s Hospital

Dr. Jim Olson

Antigen Assimilating Multispecific T Cell Engagers (MTEs) for the Treatment of Diffuse Midline Glioma (DMG)

Brain Tumors

Diffuse Midline Gliomas (DMG)


2023 & 2024

$100,000

St. Jude Children’s Research Hospital

Dr. Elizabeth Stewart

Evaluation of PARP1 Selective Inhibitor AZD5305 in Combination with DNA Damaging Agents in Ewing Sarcoma

Solid and Bone Cancers

Ewing Sarcoma


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